王永明，博士生導(dǎo)師。2010年獲得柏林自由大學(xué)博士學(xué)位；2010-2013年在斯坦福大學(xué)醫(yī)學(xué)院從事博士后研究；2013年至今在復(fù)旦大學(xué)生命科學(xué)學(xué)院工作。王永明課題組隸屬復(fù)旦大學(xué)遺傳工程國家重點(diǎn)實(shí)驗(yàn)室，主要開發(fā)新型CRISPR工具，并進(jìn)行心肌病基因治療研究。先后兩次獲得國家級(jí)人才計(jì)劃支持。
應(yīng)聘條件：
1.有小鼠操作經(jīng)驗(yàn)、基因編輯、多能干細(xì)胞培養(yǎng)或者心肌病研究背景的優(yōu)先。
2.發(fā)表過二區(qū)以上論文一篇。
工資待遇：
>40萬/年
應(yīng)聘方式：
請(qǐng)將以下應(yīng)聘材料通過電子郵件發(fā)至yonmiwang@gmail.com郵箱，郵件標(biāo)題請(qǐng)注明“應(yīng)聘王永明研究組博士后崗位”。初審合格后，將統(tǒng)一通知面試，擇優(yōu)錄用。
實(shí)驗(yàn)室鏈接：
https://life.fudan.edu.cn/e7/3d/c28175a386877/page.htm
主要研究方向：
1.開發(fā)新型CRISPR基因編輯工具。
2.運(yùn)用CRISPR技術(shù)進(jìn)行基因治療研究。
代表性成果：
1. Tao Qi, Yao Wang, Yuan Yang, Siqi Gao, Jingtong Liu, Qiang Huang, Yuwen Tian, Junnan Tang*, Wei Zheng*, Yongming Wang*. Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM. Nature Chemical Biology. 2023 Dec 6.
2. Man Qi#, Shuhong Ma#, Jingtong Liu#, Xujie Liu, Jingjing Wei, Wen-Jing Lu, Siyao Zhang, Yun Chang, Yongshuai Zhang, Kejia Zhong, Yuting Yan, Min Zhu, Yabing Song, Yundai Chen, Guoliang Hao, Jianbing Wang, Li Wang, Andrew S Lee, Xiangbo Chen*, Yongming Wang*, Feng Lan*. In vivo base editing of Scn5a rescues type 3 long QT syndrome in mice. Circulation. 2023 Nov 15.
3. Chengdong Zhang#, Yuan Yang#, Tao Qi, Yuening Zhang, Linghui Hou, Jingjing Wei, Jingcheng Yang, Leming Shi, Sang-Ging Ong, Hongyan Wang, Hui Wang*, Bo Yu*, Yongming Wang*. Prediction of base editor off-targets by deep learning. Nature communications. 2023 Sep 2;14(1):5358.
4. Yao Wang, Tao Qi,Jingtong Liu, Yuan Yang, Ziwen Wang, Ying Wang, Tianyi Wang, Miaomiao Li,Mingqing Li, Daru Lu, Alex Chia Yu Chang, Li Yang, Song Gao, Yongming Wang*, Feng Lan*. A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing. Science Advances. 2023.
5. Gao#,Yao Wang#, Tao Qi#,Jingjing Wei, Ziying Hu, Jingtong Liu, Shuna Sun*, HuihuiLiu*, Yongming Wang*. Genomeediting with natural and engineered CjCas9 orthologs. Molecular Therapy. 2023.
6. ShuaiWang#, Chen Tao#, Huilin Mao, Linghui Hou, Yao Wang, Tao Qi, Yuan Yang, Sang-GingOng, Shijun Hu*, Renjie Chai*, YongmingWang*. Identification of SaCas9 orthologs containing a conserved serineresidue that determines simple NNGG PAM recognition. PLoS Biology. 2022.
7. Jingjing Wei, LinghuiHou, Jingtong Liu, Ziwen Wang, Siqi Gao, Tao Qi, Song Gao, Shuna Sun*, Yongming Wang*. Closely related type II-CCas9 orthologsrecognize diverse PAMs. Elife. 2022.
8. ShuaiWang, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi,Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu,Renjie Chai*, Yongming Wang*. Compact SchCas9 Recognizes the Simple NNGR PAM. Advanced Science. 2021.
9. ShuhongMa#, Wenjian Jiang#, Xujie Liu#,Wen-Jing Lu, Tao Qi, Jingjing Wei, FujianWu, Yun Chang, Siyao Zhang, Yabing Song, Rui Bai, Jianbing Wang, Andrew S. Lee, Hongjia Zhang*, Yongming Wang*, Feng Lan*. Efficient Correction of a HypertrophicCardiomyopathy Mutation by ABEmax-NG. Circulation Research. 2021.
10. Ziying Hu #,Chengdong Zhang#, Shuai Wang, Siqi Gao, Jingjing Wei, Miaomiao Li, LinghuiHou, Huilin Mao, Yanyan Wei, Tao Qi, Hongmao Liu, Dong Liu, Feng Lan, Daru Lu, HongyanWang*, Jixi Li*, Yongming Wang*. Discoveryand engineering of small SlugCas9 with broad targeting range and highspecificity and activity. Nucleic Acids Research. 2021.
應(yīng)聘條件：
1.有小鼠操作經(jīng)驗(yàn)、基因編輯、多能干細(xì)胞培養(yǎng)或者心肌病研究背景的優(yōu)先。
2.發(fā)表過二區(qū)以上論文一篇。
工資待遇：
>40萬/年
應(yīng)聘方式：
請(qǐng)將以下應(yīng)聘材料通過電子郵件發(fā)至yonmiwang@gmail.com郵箱，郵件標(biāo)題請(qǐng)注明“應(yīng)聘王永明研究組博士后崗位”。初審合格后，將統(tǒng)一通知面試，擇優(yōu)錄用。
實(shí)驗(yàn)室鏈接：
https://life.fudan.edu.cn/e7/3d/c28175a386877/page.htm
主要研究方向：
1.開發(fā)新型CRISPR基因編輯工具。
2.運(yùn)用CRISPR技術(shù)進(jìn)行基因治療研究。
代表性成果：
1. Tao Qi, Yao Wang, Yuan Yang, Siqi Gao, Jingtong Liu, Qiang Huang, Yuwen Tian, Junnan Tang*, Wei Zheng*, Yongming Wang*. Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM. Nature Chemical Biology. 2023 Dec 6.
2. Man Qi#, Shuhong Ma#, Jingtong Liu#, Xujie Liu, Jingjing Wei, Wen-Jing Lu, Siyao Zhang, Yun Chang, Yongshuai Zhang, Kejia Zhong, Yuting Yan, Min Zhu, Yabing Song, Yundai Chen, Guoliang Hao, Jianbing Wang, Li Wang, Andrew S Lee, Xiangbo Chen*, Yongming Wang*, Feng Lan*. In vivo base editing of Scn5a rescues type 3 long QT syndrome in mice. Circulation. 2023 Nov 15.
3. Chengdong Zhang#, Yuan Yang#, Tao Qi, Yuening Zhang, Linghui Hou, Jingjing Wei, Jingcheng Yang, Leming Shi, Sang-Ging Ong, Hongyan Wang, Hui Wang*, Bo Yu*, Yongming Wang*. Prediction of base editor off-targets by deep learning. Nature communications. 2023 Sep 2;14(1):5358.
4. Yao Wang, Tao Qi,Jingtong Liu, Yuan Yang, Ziwen Wang, Ying Wang, Tianyi Wang, Miaomiao Li,Mingqing Li, Daru Lu, Alex Chia Yu Chang, Li Yang, Song Gao, Yongming Wang*, Feng Lan*. A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing. Science Advances. 2023.
5. Gao#,Yao Wang#, Tao Qi#,Jingjing Wei, Ziying Hu, Jingtong Liu, Shuna Sun*, HuihuiLiu*, Yongming Wang*. Genomeediting with natural and engineered CjCas9 orthologs. Molecular Therapy. 2023.
6. ShuaiWang#, Chen Tao#, Huilin Mao, Linghui Hou, Yao Wang, Tao Qi, Yuan Yang, Sang-GingOng, Shijun Hu*, Renjie Chai*, YongmingWang*. Identification of SaCas9 orthologs containing a conserved serineresidue that determines simple NNGG PAM recognition. PLoS Biology. 2022.
7. Jingjing Wei, LinghuiHou, Jingtong Liu, Ziwen Wang, Siqi Gao, Tao Qi, Song Gao, Shuna Sun*, Yongming Wang*. Closely related type II-CCas9 orthologsrecognize diverse PAMs. Elife. 2022.
8. ShuaiWang, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi,Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu,Renjie Chai*, Yongming Wang*. Compact SchCas9 Recognizes the Simple NNGR PAM. Advanced Science. 2021.
9. ShuhongMa#, Wenjian Jiang#, Xujie Liu#,Wen-Jing Lu, Tao Qi, Jingjing Wei, FujianWu, Yun Chang, Siyao Zhang, Yabing Song, Rui Bai, Jianbing Wang, Andrew S. Lee, Hongjia Zhang*, Yongming Wang*, Feng Lan*. Efficient Correction of a HypertrophicCardiomyopathy Mutation by ABEmax-NG. Circulation Research. 2021.
10. Ziying Hu #,Chengdong Zhang#, Shuai Wang, Siqi Gao, Jingjing Wei, Miaomiao Li, LinghuiHou, Huilin Mao, Yanyan Wei, Tao Qi, Hongmao Liu, Dong Liu, Feng Lan, Daru Lu, HongyanWang*, Jixi Li*, Yongming Wang*. Discoveryand engineering of small SlugCas9 with broad targeting range and highspecificity and activity. Nucleic Acids Research. 2021.
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來源鏈接：
https://life.fudan.edu.cn/21/cd/c
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