美國克利夫蘭醫(yī)學(xué)中心2024年招聘博士后職位（微生物-宿主相互作用與膽汁淤積性肝�。�

克利夫蘭醫(yī)學(xué)中心是世界最著名醫(yī)療機(jī)構(gòu)之一，機(jī)構(gòu)集合醫(yī)療、研究和教育三位一體，提供專業(yè)醫(yī)療和最新治療方案的非營利性機(jī)構(gòu)�？死�夫蘭醫(yī)學(xué)中心始建于1921年2月28日，隸屬于俄亥俄州一家非營利性公司——克利夫蘭臨床基金會，并由其經(jīng)營。

Postdoctoral Fellow – Olumuyiwa Awoniyi Lab

Cleveland, OH, US

req#: 249701

Location: Cleveland, OH

Facilities: Cleveland Clinic Main Campus

Professional Area: Research and Data

Job Code: X1004

Schedule: Full Time

Shift: Variable

Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through the Lerner Research Institute. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years.

Postdoctoral Research Associate in Microbe-Host Interactions and Cholestatic Liver Diseases

Overview: The Lerner Research Institute at Cleveland Clinic invites applications for a Postdoctoral Research Associate position within the Department of Inflammation and Immunity. This position, under the mentorship of Dr. (Olu)Muyiwa Awoniyi, focuses on the pathophysiology of cholestatic liver diseases and the interplay between gut microbiota and host health. The successful candidate will be engaged in high-impact translational research, contributing to a deeper understanding of Primary Sclerosing Cholangitis (PSC) and its associated risks.

Research Focus: The selected applicant will join the Awoniyi lab, which is at the forefront of investigating the role of the gut microbiome in PSC and its correlation with Inflammatory Bowel Disease (IBD), as well as the predisposition to hepatobiliary and colorectal cancer. Our research strategy integrates patient-derived clinical data with in vitro and in vivo experimental models, aiming to: 1. Explore the therapeutic potential of microbial strains in PSC, aiming to identify bacteria that may mitigate disease symptoms or modify its course. 2. Investigate the microbial driven therapeutic and pathogenic mechanisms of colitis-associated colorectal dysplasia in PSC-IBD models, examining microbial, intestinal mucosa and biliary contributors to disease progression. 3. Assess the effects of fecal microbial transplants from PSC patients on biliary health in germ-free mice, to understand the microbiome's influence on disease development. Requirements: Applicants must have completed a terminal degree (D.V.M., M.D., Ph.D.) in a relevant scientific discipline such as hepatology, biochemistry, immunology, microbiology, or molecular biology. Candidates should have an established track record of research excellence as evidenced by peer-reviewed publications. Proficiency in English and strong communication skills are essential. While prior experience with rodent models of liver disease is advantageous, outstanding candidates without specific experience in this field are also encouraged to apply. Application Submission: Interested candidates should email their curriculum vitae (CV) and contact information for three professional references to Dr. (Olu)Muyiwa Awoniyi at awoniyo@ccf.org.

Equal Opportunity Statement: Cleveland Clinic is committed to principles of diversity and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Our campus is a smoke-free and drug-free workplace.

Principal Investigator: Dr. Olumuyiwa Awoniyi, MD

Lerner Research Institute Department: Inflammation & Immunity

Lab Research Topics:

Microbial Therapeutics Exploration

Colorectal Dysplasia Mechanisms

Microbial Transfer Impacts

Primary Sclerosing Cholangitis

Cholestatic liver disease models

For more information about the lab’s research, please visit: https://www.lerner.ccf.org/inflammation-immunity/awoniyi/ or contact Dr. Awoniyi at awoniyo@ccf.org.

Job Responsibilities:

Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation

Designing and conducting experiments.

Analyzing data and preparing manuscripts for peer-reviewed journals.

Disseminating findings via conference presentations and scientific publications.

Collaborating within multidisciplinary teams to expand the scope of research

Education:

PhD or MD/PhD required

MD with relevant laboratory experience may substitute for PhD

Languages:

English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

Previous experience in a research or academic setting. Graduate student experience meets this requirement.

Scientific writing experience

Additional Preferred Qualities:

Pursuing extramural funding opportunities, including fellowships.

Completed a terminal degree (D.V.M., M.D., Ph.D.) in a relevant scientific discipline such as hepatology, biochemistry, immunology, microbiology, or molecular biology.

Physical Requirements:

Ability to perform work in a stationary position for extended periods

Ability to operate a computer and other office equipment

Ability to communicate and exchange accurate information

Ability to distinguish color

Manual dexterity to handle specimens and repair equipment

Ability to lift and transport equipment or specimens weighing up to 20 pounds

May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment:

PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

CV

Three references

All application materials should be submitted directly via email to name at awoniyo@ccf.org.

Keywords: Postdoc, Research, LRI, Liver disease, Microbiota, Gut-liver-axis, Hepatobiliary research, Murine models, Microbial therapeutics, Primary Sclerosing Cholangitis

Pay Range

Minimum hourly: $0.01

Maximum hourly: $333,340.26

The pay range displayed on this job posting reflects the anticipated range for new hires. While the pay range is displayed as an hourly rate, Cleveland Clinic recruiters will clarify whether the compensation is hourly or salary. A successful candidate’s actual compensation will be determined after taking factors into consideration such as the candidate’s work history, experience, skill set, and education. This is not inclusive of the value of Cleveland Clinic’s benefits package, which includes among other benefits, healthcare/dental/vision and retirement.

The policy of Cleveland Clinic Health System and its system hospitals (Cleveland Clinic Health System) is to provide equal opportunity to all of our caregivers and applicants for employment in our tobacco free and drug free environment. All offers of employment are followed by testing for controlled substance and nicotine. All new caregivers must clear a nicotine test within their 90-day new hire period. Candidates for employment who are impacted by Cleveland Clinic Health System’s Smoking Policy will be permitted to reapply for open positions after one year.

Cleveland Clinic Health System administers an influenza prevention program. You will be required to comply with this program, which will include obtaining an influenza vaccination on an annual basis or obtaining an approved exemption.

Decisions concerning employment, transfers and promotions are made upon the basis of the best qualified candidate without regard to color, race, religion, national origin, age, sex, sexual orientation, marital status, ancestry, status as a disabled or Vietnam era veteran or any other characteristic protected by law. Information provided on this application may be shared with any Cleveland Clinic Health System facility.

Please review the Equal Employment Opportunity poster

Cleveland Clinic Health System is pleased to be an equal employment employer: Women / Minorities / Veterans / Individuals with Disabilities

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