牛津大學(xué)（University of Oxford；勛銜：Oxon或Oxf），簡(jiǎn)稱“牛津”（Oxford），位于英國(guó)牛津，是一所公立研究型大學(xué)，采用傳統(tǒng)學(xué)院制。是羅素大學(xué)集團(tuán)成員，被譽(yù)為“金三角名校”和“G5”之一。牛津大學(xué)的具體建校時(shí)間已不可考，但有檔案明確記載的最早的授課時(shí)間為1096年，之后在1167年因得到了英國(guó)王室的大力支持而快速發(fā)展。

Postdoctoral Researcher In Medicine (Molecular Biology)

University Of Oxford

Description

Postdoctoral Researcher in Medicine (Molecular Biology)

RDM Investigative Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford

We wish to hire a talented and highly motivated molecular biology postdoc to investigate the translational implications of mechanisms underlying human tissue T cell immune responses. Graham Ogg's group is studying lipid-specific T cells in the blood and skin in order to define disease pathogenesis and to identify targets for future therapeutic intervention. Samples are taken from well-characterised patients seen by Graham Ogg, as a consultant dermatologist. Lipid-specific and peptide-specific T cells are isolated and analysed through single cell and bulk RNAseq in order to relate clonal T cell populations expressing individual TCR with associated functional responses. The data will be used to characterise responses to novel antigens, as well as defining the responding T cells and TCR for future therapeutic development, including for inflammatory disease and cancer. Tissue spatial protein and RNA expression analyses are also being actively pursued.

The successful applicant will hold a Ph.D. in a relevant subject (or close to submission) including a solid background in CD1a T cell immunology and have extensive experience of T cell immunology, particularly on CD1a related work The work will be undertaken in the MRC Human Immunology Unit at the Weatherall Institute of Molecular Medicine with collaborative work at other sites across the science campus.

The successful candidate will conduct research in a dynamic and highly collaborative environment of an internationally leading research institute. They will benefit from the institute and wider university expertise in immunology, computational biology, machine-learning and big-data science. There will be opportunities to develop new models to explain differential responses of T cell populations during homeostasis, inflammation and cancer.

The post is fixed term for 2 years in the first instance.

Applications for this vacancy are to be made online. You will be required to upload a supporting statement and CV as part of your online application.

Only applications received before 12.00 midday on Friday 28/10/2022 will be considered.

Contact Person : Senior HR Officer Vacancy ID : 161117 Contact Phone : Closing Date & Time : 28-Oct-2022 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : hr@rdm.ox.acuk Salary (£) : £34,308 - £42,155 p.a.

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