美國(guó)西北大學(xué)2025年招聘博士后職位（病毒學(xué)/神經(jīng)科學(xué)）

西北大學(xué)（Northwestern University），簡(jiǎn)稱NU，是一所位于伊利諾伊州埃文斯頓市的私立研究型大學(xué)，是十大聯(lián)盟（Big Ten Conference）創(chuàng)始成員和北美頂尖大學(xué)學(xué)術(shù)聯(lián)盟美國(guó)大學(xué)協(xié)會(huì)（AAU）的成員之一，“新常春藤”院校，并入選英國(guó)政府“高潛力人才簽證計(jì)劃”。

Postdoctoral positions in Virology/Neuroscience

Employer

Northwestern University Feinberg School of Medicine

Location

Chicago, Illinois

Salary

Commensurate with qualifications

Closing date

15 Feb 2025

Website

https://labs.feinberg.northwestern.edu/naghavi/index.html

Postdoctoral positions in Virology/Neuroscience

Postdoctoral positions are available on NIH funded research projects to study the biology of virus infection in different cell types and its links to neurodegeneration, in the Naghavi Lab. Dr. Naghavi is a Professor at the Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago. The Feinberg School of Medicine is located in the center of downtown Chicago. Additional information about the Naghavi lab can be found at http://labs.feinberg.northwestern.edu/naghavi/

Our research focuses on infection by Human Immunodeficiency Virus type 1 (HIV-1), a retrovirus and causative agent of acquired immunodeficiency syndrome (AIDS). In addition to suppressing the immune system, rendering victims susceptible to opportunistic infections, HIV-1 can cross the blood-brain barrier and cause serious damage to the central nervous system, ultimately leading to a broad spectrum of disorders that range from mild impairment to severe HIV-associated dementia.

Our research has had a long-term focus on host factors that regulate HIV-1 infection in a variety of cell types, including microglia and primary neurons. In one area of our research, we have identified specialized microtubule regulators and kinesin adaptor proteins that are exploited by HIV-1 to promote intracellular transport and infection. In a second area of research, we discovered that Amyloid Precursor Protein (APP) is highly expressed in microglia and limits HIV-1 spread; evasion of this restriction by HIV-1 results in the secretion of neurotoxic amyloids. Modulating how APP and HIV-1 interact may provide therapeutic opportunities that we are currently exploring. Both projects employ a range of molecular biological approaches, as well as live cell imaging of virus movement and microtubule dynamics in microglia cells.

Candidates must have a PhD or equivalent with strong research experience in virology, neuroscience and/or molecular biology. Applicants with experience in fluorescence microscopy and live imaging are particularly encouraged to apply.

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