招聘簡(jiǎn)介：
由Thomas Voets領(lǐng)導(dǎo)的離子通道研究實(shí)驗(yàn)室（LICR）是一個(gè)充滿活力的國(guó)際研究團(tuán)隊(duì)，位于Vib-Ku-Leuven腦與疾病研究中心（Vib-CBD）和Ku-Leuven細(xì)胞與分子醫(yī)學(xué)部。
LICR的研究主要集中在瞬時(shí)受體電位（TRP）離子通道，我們使用多種分子、細(xì)胞和體內(nèi)方法來(lái)研究其功能特性、細(xì)胞調(diào)節(jié)和（病理）生理作用。此外，通過(guò)與臨床和工業(yè)合作伙伴的密切合作，我們旨在將這些知識(shí)轉(zhuǎn)化為新的基于TRP通道的治療方法，以治療慢性疼痛、糖尿病、心臟病和膀胱功能障礙等重要疾病。
職位描述
我們目前正在尋找一位才華橫溢、積極進(jìn)取的博士后研究員加入我們的團(tuán)隊(duì)，研究TRP和相關(guān)離子通道在軀體感覺(jué)和疼痛中的作用。
總的目標(biāo)是闡明確定皮膚和其他靶器官中感覺(jué)通道的定位和功能的細(xì)胞和亞細(xì)胞過(guò)程，明確這些過(guò)程在病理性疼痛狀態(tài)下的影響，并利用這些知識(shí)設(shè)計(jì)慢性疼痛的新治療策略。在這一研究背景下，成功的候選人將有很大的自由去發(fā)展自己的研究問(wèn)題和項(xiàng)目。
英文原文:
About the Lab
The Laboratory of Ion Channel Research (LICR), headed by Thomas Voets, is a vibrant and international research team, embedded in the VIB-KU Leuven Center for Brain and Disease Research (VIB-CBD) and the KU Leuven Department of Cellular and Molecular Medicine.
Research within LICR is focused on transient receptor potential (TRP) ion channels, and we use a large variety of molecular, cellular and in vivo approaches to study their functional properties, cellular regulation and (patho)physiological roles. Moreover, through intense collaborations with clinical and industrial partners, we aim at translating this knowledge into new TRP channel-based therapies for important medical conditions including chronic pain, diabetes, cardiac disease and bladder dysfunction.
Job description
We are currently looking for a talented and motivated postdoctoral researcher to join our team investigating the role of TRP and related ion channels in somatosensation and pain.
The overall objective is to elucidate cellular and subcellular processes that determine the localization and function of sensory channels in the skin and other target organs, to define how these processes are affected in pathological pain states, and to use this knowledge to design novel treatment strategies for chronic pain. Within this research context, the successful candidate will have a large degree of freedom to develop her/his research question and project.
Profile
Essential:
A PhD in biomedical sciences, (neuro)biology, biophysics, bioinformatics or related field
Effective written and verbal English communication skills
A strong publication record with first-author papers in well-established international journals
Desirable but not required:
Hands-on experience with the following is an asset: super-resolution imaging, single-cell transcriptomics, in vivo imaging, patch-clamp electrophysiology, pain models, bioinformatics
We offer
An internationally renowned research team (LICR), within a top quality neuroscience center (VIB-CBD), located in Europe’s most innovative university (KU Leuven)
Direct access to state-of-the-art infrastructure and core facilities at VIB-CBD and KU Leuven
Excellent personal development opportunities in both scientific and academic career skills
Financial support is available for 3 years but the successful candidate is encouraged to obtain an independent fellowship (Marie-Curie, EMBO, or National funding organizations) during this time.
How to apply?
Please complete the online application, including the following items:
Your CV with publication list
The names and email addresses of 2 referees
A one-page letter outlining your motivation and research vision
For more information please contact Thomas Voets.
For extra information:
https://gbiomed.kuleuven.be/LICR
https://cbd.vib.be/careers/
Have a look at some of our recent publications:
• Vandewauw I, De Clercq K, Mulier M, Held K, Pinto S, Van Ranst N, Segal A, Voet T, Vennekens R, Zimmermann K, Vriens J, Voets T: A TRP channel trio mediates acute noxious heat sensing. Nature 2018, 555:662-666.
• Janssens A, Gees M, Toth BI, Ghosh D, Mulier M, Vennekens R, Vriens J, Talavera K, Voets T: Definition of two agonist types at the mammalian cold-activated channel TRPM8. Elife 2016, 5.
• Ghosh D, Pinto S, Danglot L, Vandewauw I, Segal A, Van Ranst N, Benoit M, Janssens A, Vennekens R, Vanden Berghe P, Galli T, Vriens J, Voets T: VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Nature Communications 2016, 7:10489.
• Uvin P, Franken J, Pinto S, Rietjens R, Grammet L, Deruyver Y, Alpizar YA, Talavera K, Vennekens R, Everaerts W, De Ridder D, Voets T: Essential role of transient receptor potential M8 (TRPM8) in a model of acute cold-induced urinary urgency. European Urology 2015, 68:655-661.
• Vriens J, Nilius B, Voets T: Peripheral thermosensation in mammals. Nature Reviews Neuroscience 2014, 15:573
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