法國國家健康與醫(yī)學研究院（INSERM）2023年招聘博士后職位（免疫學）
法國國家健康與醫(yī)學研究院（法文為：Institut national de la santé et de la recherche médicale），簡稱“Inserm”，成立于1964年，是一所總部位于法國巴黎的國家級公共科學和技術(shù)研究機構(gòu)，其前身是成立于1941年的法國國家衛(wèi)生研究院，由法國衛(wèi)生部和研究部共同管理。Inserm是法國唯一一個完全致力于人類健康的公共研究組織，參與從研究到治療的全過程，其宗旨通過增進對生命和疾病的知識、創(chuàng)新治療方法和公共衛(wèi)生研究，促進全人類健康。
Postdoctoral Researcher In Immunology : Mechanisms Of Hepatitis E Virus Immunopathogenesis In Solid Organ Transplant Recipients
Universities and Institutes of France
France
November 01, 2023
Contact:N/A
Offerd Salary:Negotiation
Location:N/A
Working address:N/A
Contract Type:Other
Working Time:Full time
Working type:N/A
Ref info:N/A
28 Aug 2023
Job Information
Organisation/Company
INSERM
Department
U1291
Research Field
Biological sciences » Biology
Medical sciences » Health sciences
Researcher Profile
Recognised Researcher (R2)
Country
France
Application Deadline
1 Nov 2023 - 23:00 (Europe/Paris)
Type of Contract
Temporary
Job Status
Full-time
Offer Starting Date
1 Jan 2024
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
Yes
Offer Description
Project Title
Postdoctoral Researcher in Immunology : Mechanisms of hepatitis E virus immunopathogenesis in solid organ transplant recipients
Research Project
Hepatitis E virus genotype 3 (HEV) establishes mostly asymptomatic, self- limiting infection in immunocompetent individuals. However, in immunocompromised patients with solid organ transplant the infection progresses frequently to a chronic course. To date, the mechanisms involved in viral persistence remain to be discovered.
The overall objective of the current project is to investigate, at the cellular and molecular levels, the function of immune cells, particularly T cells, at the acute stage of the infection in order to unveil their role in viral persistence/clearance. To this end, cryopreserved PBMC and plasma samples (collected at the early and late phases of the infection) from infected and uninfected transplanted patients will be used. T cell subsets will be studied with embedded levels of analysis (phenotype, function, metabolism, gene expression) by flow cytometry and single cell Cite-seq. Additional metabolomics and proteomics studies will also be conducted on plasma samples.
Main Activities
· To be responsible for the development of the research project: plan experiments, analyze and interpret experimental data, report regularly to the supervisor and team members on scientific activities and maintain accurate and up-to-date records of all findings.
· To maintain an up-to-date awareness of relevant publications in the area of research.
· To participate in publications and funding request writing.
· To train and supervise junior members of the team.
Associated Activities
· To participate in the team project (experiments and analyses).
Scientific Environment
The Toulouse Institute for Infectious and Inflammatory diseases (INFINITy) provides a stimulating environment to perform state-of-the-art research in immunology and infectious diseases, with integrated on-site technological facilities. Research teams at the Center host international trainees of various nationalities, ranging from undergraduate students to postdocs. External seminars and lab meetings are held in English.
The host team, headed by Dr. Jabrane-Ferrat is currently composed of 9 members working collaboratively. The candidate will be supervised by the Dr. H. El Costa (PI). The research project will be in close collaboration with the French Nation Reference Center for entero-transmissible hepatitis E (Pr. J. Izopet and Dr. F. Abravanel).
Requirements
Research Field
Biological sciences » Biology
Education Level
PhD or equivalent
Skills/Qualifications
· The applicant should have a strong expertise and proven research skills in T cells biology and immunology techniques such as multiparametric flow cytometry (FACS Symphony A5, Spectral Cytek Aurora) and metabolism analyses (Seahorse, Scenith).
· Proven practical experience in bioinformatics/Omics are mandatory.
· Experience using flow cytometry analysis software (OMIQ, FlowJo), statistical programs such as Prism and Microsoft office programs (Excel, PowerPoint, Word).
· Excellent communication skills, team spirit, capacity to work autonomously and deliver results on time.
Specific Requirements
PhD in immunology with 2 years of postdocoral experience.
Handling human samples in a 2/3 level containment laboratory.
Possible outside working hours.
Languages
ENGLISH
Level
Excellent
Languages
FRENCH
Level
Basic
Research Field
Biological sciences » Biology
Years of Research Experience
1 - 4
Additional InformationWork Location(s)
Number of offers available
1
Company/Institute
Toulouse Institute for Infectious and Inflammatory Diseases
Country
France
City
Toulouse
Postal Code
31024
Street
CHU Purpan
Geofield
Where to apply
hicham.el-costa@inserm.fr
Contact
City
Toulouse
Website
https: // www. infinity.inserm.fr/en/
Street
1 place, docteur Baylac
Postal Code
31024
hicham.el-costa@inserm.fr
Phone
0562748370
STATUS: EXPIRED
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