英國(guó)MRC倫敦醫(yī)學(xué)科學(xué)研究所2024年招聘博士后（染色質(zhì)與發(fā)育）

英國(guó)醫(yī)學(xué)研究理事會(huì)(Medical Research Council，簡(jiǎn)稱MRC)成立于1913年，隸屬于英國(guó)研究理事會(huì)，是一個(gè)由英國(guó)公共資金建立的國(guó)家級(jí)政府機(jī)構(gòu)，是英國(guó)七大國(guó)家級(jí)研究理事會(huì)之一，其宗旨是資助為改善人們健康狀況而開展的醫(yī)學(xué)研究。

MRC Postdoctoral Research Scientist – Chromatin and Development – LMS 2327

MRC London Institute of Medical Sciences

United Kingdom

February 11, 2024

Contact:N/A

Offerd Salary:£3,913 & £1,472

Location:N/A

Working address:N/A

Contract Type:Other

Working Time:Negotigation

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MRC PostdoctoralResearch Scientist

Mechanisms of Transposable Element Dysregulationin Human Disease

Salary: £39,375 plus London Allowances (£3,913 & £1,472) per annum

3-year fixed term

London, UK

The Percharde lab previously discovered that the transposon, LINE1, is essential in embryonic stem cells and embryos, highlighting unexpected roles for transposons in development (Percharde et al., Cell 2018), and recently described new mechanisms in development for transposon regulation (Xie et al., Genes Dev 2022). The Vaquerizas lab studies how chromatin, 3D genome organisation, and repetitive elements influence development and disease (Kruse et al., 2019, Chang et al., Genome Res 2022).

Building on these advances, the successful candidate will work to elucidate how epigenetic dysregulation of pathways controlling gene and transposon expression and 3D genome organisation drives human disease. For detailed information about the work of both groups, please visit: https: // lms.mrc.ac.uk/research-group/chromatin-and-development/, www. perchardelab.com and https: // lms.mrc.ac.uk/research-group/developmental- epigenomics/.

The ideal candidate will have a background in genome regulation, transposable element biology or related fields, and prior extensive experience in computational analysis of high-throughput genetic analysis techniques, such as Hi-C, ATAC-seq, and RNA-seq. The position is available to be filled spring 2024, but the start date can be flexible.

This post is an MRC Postdoctoral Scientist position reflective of the increased experience and responsibilities the successful candidate will have, who will lead their own project and may work collaboratively on 1-2 others. We offer a highly attractive benefits package including competitive salary, excellent holiday entitlement and generous pension scheme.

This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply.

Final appointment will be subject to pre-employment screening

Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly installments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.

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