美國賓夕法尼亞大學化學系2025年博士后招聘
賓夕法尼亞大學 （University of Pennsylvania），簡稱賓大（UPenn, Penn），位于美國賓夕法尼亞州的費城，是一所享譽世界的私立研究型大學，常春藤盟校（Ivy League）成員，美國大學協(xié)會創(chuàng)始成員，全球大學校長論壇成員，入選英國政府“高潛力人才簽證計劃” 院校名單。
Post-Docs in the Virgil Percec lab at the University of Pennsylvania, Department of Chemistry
Employer
University of Pennsylvania, Department of Chemistry
Location
Philadelphia, Pennsylvania (US)
Salary
Commensurate with education and experience
Closing date
Mar 6, 2025
Post-docs in the Virgil Percec Lab at the University of Pennsylvania (Penn), Department of Chemistry in the design, synthesis and structural analysis combined with in vivo activity for one-component delivery systems for mRNA
Virgil Percec Lab together with Drew Weissman Lab from the Perelman School of Medicine at Penn discovered and developed a one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA (JACS 2021, 143, 12315). IAJDs co-assemble with mRNA into dendrimersome nanoparticles (DNPs) which eliminate some of the disadvantages and complement the four-component lipid nanoparticles (LNPs) elaborated and employed in the delivery of mRNA from Covid 19 vaccines. These postdoc positions are immediately available and require excellent background in organic synthesis, supramolecular chemistry and characterization by NMR, HPLC, MALDI-TOF combined with in vivo experiments performed in collaboration with Weissman Laboratory. The goal of these positions is to develop a Nanoperiodic Table correlating the primary structure of IAJDs with in vivo mRNA delivery. This work is expected to impact the new field of nanomedicine by creating new, less expensive and more activer vaccines and therapeutics based on mRNA
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