美國(guó)賓夕法尼亞大學(xué)化學(xué)系2024年招聘博士后職位
賓夕法尼亞大學(xué)（英文：University of Pennsylvania），簡(jiǎn)稱賓大（英文：UPenn, Penn），位于賓夕法尼亞州費(fèi)城市，是一所私立研究型大學(xué)，常春藤盟校之一，美國(guó)大學(xué)協(xié)會(huì)創(chuàng)始成員，全球大學(xué)校長(zhǎng)論壇成員。大學(xué)創(chuàng)建于1740年，是美國(guó)第五古老的高等教育機(jī)構(gòu)，也是美國(guó)第一所從事科學(xué)技術(shù)和人文教育的現(xiàn)代高等學(xué)校。該校的創(chuàng)建者是美利堅(jiān)合眾國(guó)著名開國(guó)元?jiǎng)字坏谋窘苊?middot;富蘭克林。
Postdoctoral researcher
Department of Chemistry, University of Pennsylvania
The Cooperman laboratory in the Chemistry Department of the University of Pennsylvania is seeking to recruit a postdoctoral student with a strong interest in applying biochemical and biophysical approaches to elucidate the mechanism and regulation of protein synthesis, with application to both the development of potent, nontoxic drugs to treat nonsense mutation diseases and the elucidation of how epitranscriptome modifications of mRNA, tRNA, and rRNA interact to reprogram translation during cancer development. These efforts will build on our accomplishments in developing and applying a highly purified, eukaryotic cell-free protein synthesis system, as described in several publications (Zhang et al., Elife 2016 5:e13429; Ng et al., ACS Med Chem Lett. 2018 9:1285-1291; PNAS 2021 118, e202059911; Huang et al., Nature Comm 2022 13:2413; Ghelfi et al., Biomolecules. 2023;13(2):242) and current work. The successful applicant should be mechanistically oriented with expertise in biochemical and molecular biological approaches. Qualifications include a recent Ph.D. in biochemistry, chemical biology, molecular biology or a related field and a strong interest in protein synthesis. Familiarity with bioinformatic tools is a plus. Applicants must have a strong work ethic, communication & organization skills, and a willingness to think about and learn new methodologies as projects evolve. Applicants should send a cover letter and CV with contact information for three references to Barry Cooperman (cooprman@pobox.upenn.edu).
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