職位描述：

　　NeuherbergbeiMünchen，巴伐利亞，德國

　　工作組：

　　功能表觀遺傳學(xué)研究所

　　研究領(lǐng)域：

　　科學(xué)/博士后職位

　　開始日期：

　　2019年4月1日

　　合同期限：

　　2021年3月31日

　　職位描述：

　　作為德國環(huán)境健康研究中心，HelmholtzZentrumMünchen致力于開發(fā)個性化醫(yī)療方法，以預(yù)防和治療糖尿病，過敏癥和肺病等主要常見疾病。為此，它研究了遺傳，環(huán)境因素和生活方式的相互作用。

　　慕尼黑亥姆霍茲中心的功能表觀遺傳學(xué)研究所（IFE）專注于了解表觀遺傳機(jī)制如何調(diào)節(jié)細(xì)胞的身份和功能。具體而言，我們想要揭示染色質(zhì)修飾如何通過基因表達(dá)的變化來調(diào)節(jié)這些過程。我們的研究包括下一代測序（ChIPseq，RNAseq，CLIP等），單細(xì)胞方法，生物化學(xué)以及各種發(fā)育和細(xì)胞生物學(xué)系統(tǒng)。

　　對于我們的研究團(tuán)隊，我們目前正在尋找一個

　　表觀遺傳學(xué)中的PostDoc（f / m / d）

　　2019/0047

　　職位描述

　　對于染色質(zhì)生物化學(xué)，表觀遺傳學(xué)和表型遺傳學(xué)的間期項目，我們正在尋找具有強(qiáng)大研究背景，表觀遺傳學(xué)或染色質(zhì)領(lǐng)域經(jīng)驗以及經(jīng)過驗證的出版記錄的PostDoc。成功的候選人將研究新的染色質(zhì)修飾途徑，包括我們最近發(fā)現(xiàn)的DNA和RNA修飾，以解決表觀遺傳學(xué)中的一個核心問題：細(xì)胞環(huán)境控制基因表達(dá)程序和疾病狀態(tài)（如癌癥）的機(jī)制是什么？

　　該項目將涉及體外和體內(nèi)方法的結(jié)合，包括不同的NGS（組學(xué)）技術(shù)及其分析，以及開發(fā)新的創(chuàng)新技術(shù)，以解決單細(xì)胞和低輸入材料的機(jī)制。它旨在使申請人在確定其方向方面發(fā)揮重要作用，同時受益于激烈的國際合作以及其他研究所成員的深刻的表觀遺傳學(xué)和染色質(zhì)背景。

　　你的資格

　　這個職位的候選人應(yīng)該：

　　生物學(xué)或相關(guān)領(lǐng)域的博士生染色質(zhì)研究的強(qiáng)大研究背景，具有非常好的出版記錄至少有以下兩個領(lǐng)域的經(jīng)驗是必不可少的：染色質(zhì)生物化學(xué)ChIP seq和RNA seq技術(shù)（包括數(shù)據(jù)分析）單細(xì)胞方法流利的英語需要德語知識不需要

　　我們的意向

　　在HelmholtzZentrumMünchen，您可以與領(lǐng)先的研究人員共同研究糖尿病，慢性肺病和過敏等環(huán)境疾病的發(fā)展，預(yù)防和治療。為了進(jìn)一步促進(jìn)您的專業(yè)發(fā)展，我們提供廣泛和有針對性的研究培訓(xùn)和職業(yè)計劃。我們通過靈活的工作時間模型，職業(yè)健康管理，兒童日托設(shè)施，兒童保育補(bǔ)貼，老年護(hù)理以及其他咨詢和支持服務(wù)，支持工作與私人生活之間的和解。

　　薪酬和福利符合公共服務(wù)集體協(xié)議（TV EntgO Bund）。該職位（最初）限于2年。

　　作為全面質(zhì)量獎的持有者，我們促進(jìn)機(jī)會均等。為了增加女性擔(dān)任管理職位的比例，我們很樂意收到相應(yīng)的申請。合格的身體殘疾申請人將被優(yōu)先考慮。

　　我們期待收到您的綜合在線申請，直到2019年3月31日。

　　英文原文：

　　Neuherberg bei München, Bavaria, Germany

　　Work group:

　　Institute of Functional Epigenetics

　　Area of research:

　　Scientific / postdoctoral posts

　　Starting date:

　　01.04.2019

　　Contract time limit:

　　31.03.2021

　　Job description:

　　As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

　　The Institute of Functional Epigenetics (IFE) at the Helmholtz Center Munich focuses on understanding how epigenetic mechanims regulates cellular identity and function. Specifically we want to unravel how chromatin modifications regulate these processes through changes in gene expression. Our research includes next generation sequencing (ChIPseq, RNAseq, CLIP etc.), single cell approaches, biochemistry as well as various developmental and cell biology systems.

　　For our research team we are currently looking for a

　　PostDoc in Epigenetics (f/m/d)

　　2019/0047

　　Job Description

　　For a project on the interphase between chromatin biochemistry, epigenetics and epitranscriptomics we are looking for a PostDoc with a strong research background, experience in the epigenetics or chromatin field and a proven publication record. The successful candidate will study novel chromatin modifying pathways including DNA and RNA modifications, which we have recently identified, to address a central question in epigenetics: what are the mechanisms via which the cellular environment controls gene expression programs and disease states, such as cancer?

　　This project will involve a combination of in vitro and in vivo approaches, including different NGS (omics) techniques and their analysis as well the development of novel innovative technologies to address mechanism in single cells and low-input material. It is designed to allow the applicant to play a major role in determining its direction and at the same time benefit from intense international collaborations as well as the profound epigenetics and chromatin background of the other Institute members.

　　Your Qualification

　　Candidates for this position should have:

　　PhD in biology or a related field Strong research background in chromatin research with a very good publication recordExperience in at least two of the following fields is essential:Chromatin biochemistryChIP seq and RNA seq techniques (including data analysis)Single cell approachesFluent English is requiredknowledge of German is not required

　　Our Offer

　　At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention and treatment of environmental diseases such as diabetes, chronic lung diseases and allergies. In order to further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.

　　Remuneration and benefits are in accordance with the collective agreement for the public service (TV EntgO Bund). The position is (initially) limited to 2 years.

　　As a holder of the Total E-Quality Award, we promote equality of opportunity. In order to increase the proportion of women in management positions, we would be pleased to receive corresponding applications. Qualified applicants with physical disabilities will be given preference.

　　We are looking forward to receiving your comprehensive online application until March 31st 2019.

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