招聘簡介：

　　研究科學(xué)家 -  Kapil N. Bhalla博士的實驗室

　　·德克薩斯大學(xué)MD安德森癌癥中心

　　·地點：德克薩斯州休斯頓

　　·工作號碼：7057422（參考號：127265）

　　·發(fā)布日期：2019年5月24日

　　·申請截止日期：開放至填寫

　　職位描述

　　研究科學(xué)家 -  Kapil N. Bhalla博士的實驗室

　　Kapil N. Bhalla博士目前正在尋找一名高級研究科學(xué)家，負(fù)責(zé)在NIH資助的實驗室進(jìn)行研究。本實驗室基礎(chǔ)和轉(zhuǎn)化研究的重點包括與表觀遺傳機(jī)制相關(guān)的生物學(xué)和發(fā)育療法，包括組蛋白去乙酰化酶，甲基轉(zhuǎn)移酶和去甲基化酶，BET蛋白，以及熱休克蛋白及其癌癥相關(guān)客戶蛋白調(diào)節(jié)細(xì)胞的伴侶生物學(xué)。人白血病干/祖細(xì)胞的生長，分化和存活。合格的候選人必須擁有博士學(xué)位。在生物學(xué)，生物科學(xué)或相關(guān)生命科學(xué)領(lǐng)域，以及對癌癥研究的濃厚興趣和經(jīng)驗。候選人必須在與Bhalla博士實驗室研究重點相關(guān)的領(lǐng)域完成至少3年的博士后研究。合格的候選人必須有能力在設(shè)計和進(jìn)行實驗室研究時進(jìn)行故障排除。利用涉及基因轉(zhuǎn)染的分子研究，通過RNA-Seq分析基因表達(dá)，QPCR，免疫印跡和流式細(xì)胞術(shù)，以及染色質(zhì)免疫沉淀研究，使用2D凝膠評估蛋白質(zhì)生物化學(xué)和酵母雙雜交系統(tǒng)的經(jīng)驗和出版物，和組織培養(yǎng)技術(shù)是必需的。非常需要具有利用CRISPR技術(shù)進(jìn)行基因編輯和利用共聚焦顯微鏡進(jìn)行分子成像的能力。還需要在異種移植和基因工程的癌癥和/或白血病動物模型以及共聚焦顯微鏡中的經(jīng)驗。提供優(yōu)秀的研究環(huán)境，新的實驗室和核心設(shè)施。

　　英文原文：

　　Research Scientist - Dr. Kapil N. Bhalla's Laboratory

　　·         University of Texas MD Anderson Cancer Center

　　·         Location: Houston, TX

　　·         Job Number: 7057422 (Ref #: 127265)

　　·         Posting Date: May 24, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　Research Scientist - Dr. Kapil N. Bhalla's Laboratory

　　Dr. Kapil N. Bhalla is currently seeking a Senior Research Scientist who will be responsible for conducting research in his NIH-funded laboratory. The focus of the basic and translational research in this laboratory includes the biology and developmental therapeutics related to epigenetic mechanisms involving histone deacetylases, methyltransferases and demethylases, BET proteins, as well as the chaperone biology of heat shock proteins and their cancer relevant client proteins regulating cell growth, differentiation and survival of the human leukemia stem/progenitor cells. The qualified candidate must possess a Ph.D. in Biology, Biological Science or related Life Sciences, and a keen interest and experience in cancer research. The candidate must have completed at least a 3 year Post-doctoral fellowship in an area relevant to the focus of research in Dr. Bhalla’s laboratory. The qualified candidate must have the ability to troubleshoot in the design and conduct of laboratory studies. Experience and publications utilizing molecular studies involving gene transfection, analysis of gene expression through RNA-Seq, QPCR, immunoblots and flow cytometry, as well as in chromatin immunoprecipitation studies, evaluation of protein biochemistry with 2D gels and the yeast-two-hybrid system, and tissue culture techniques is required. Experience in the ability to utilize CRISPR technology for gene editing and to utilize confocal microscopy for molecular imaging is highly desired. Experience in xenograft and genetically-engineered animal models of cancer and/or leukemia, and confocal microscopy is also desired. An outstanding research environment, new laboratory and core facilities are provided.

　　KEY FUNCTIONS

　　Research Design and implementation

　　Plans, organizes, coordinates, directs and conducts scientific research projects. Develops and maintains standard procedures and protocols to ensure the quality and integrity of the procedures performed. Coordinates with other investigators to provide appropriate support on analytical techniques. Maintains detailed experimental records, evaluates resulting research data, and presents findings to physicians and/or professional groups.

　　Data Analysis

　　Analyzes and evaluates research data and revises techniques and approaches to work problems. Works with the Principal Investigator on projects in the area of biomarker development and leukemia biology. Participates in adopting new techniques and learning new skills to enhance research efforts.

　　Lab Development/Publications

　　Supervises, mentors, and counsels trainees and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment and safety procedures. Publications/Manuscripts and Presentations. Contributes to manuscripts and prepares documents for publication. Compiles, writes, and submits reports to superior. Presents results at national meetings.

　　EDUCATION

　　Required: PhD in one of the natural sciences or related field or Medical degree.

　　EXPERIENCE

　　Required: With PhD, no experience required. With Medical degree, two years of experience in experimental or scientific work.

　　Preferred: With PhD must have completed at least a 3 year Post-doctoral fellowship in an area relevant to the focus of research in Dr. Bhalla's laboratory.

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