Sanford Burnham Prebys醫(yī)學(xué)研究所癌癥和神經(jīng)系統(tǒng)疾病博士后招聘
We seek a highly motivated postdoctoral fellow to study the role of epitranscriptomics or messenger RNA modification in human disease. Post-transcriptional modification on mRNA has emerged as an essential gene regulatory mechanism. My lab focuses on the most abundant mRNA modification, namely N6-methyladenosine or m6A. We identified a protein complex that governs m6A formation (Nature Cell Biology 16 (2): 191-8, Feb. 2014). Using loss-of-function studies, we reported the requirement of m6A in brain development (Nature Neuroscience 21 (2): 195-206, Feb. 2018). Mechanistically, we discovered
that m6A regulates gene expression via shortening mRNA half-life or crosstalk with histone modifications. Currently, we are investigating roles of m6A mRNA modification in cancer and in neurological disorders using a combination of mouse genetics, biochemistry, cell biology, and high throughout sequencing technologies.
為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國博士人才網(wǎng)）
中國-博士人才網(wǎng)發(fā)布
聲明提示：凡本網(wǎng)注明“來源：XXX”的文/圖等稿件，本網(wǎng)轉(zhuǎn)載出于傳遞更多信息及方便產(chǎn)業(yè)探討之目的，并不意味著本站贊同其觀點或證實其內(nèi)容的真實性，文章內(nèi)容僅供參考。
