研究所簡介

踐行"健康中國"戰(zhàn)略，針對中國市場打造生命科學(xué)與生物醫(yī)藥產(chǎn)業(yè)鏈，推動粵港澳大灣區(qū)創(chuàng)新基地建設(shè)。借助斯克瑞普斯研究所"從實(shí)驗(yàn)到臨床"的成功模式，在深圳創(chuàng)辦創(chuàng)新藥物研發(fā)與推廣平臺。

篩選系統(tǒng)及化合物庫建設(shè)：建立全自動超高通量篩選系統(tǒng)(uHTS)，具有苗頭分子分揀和化合物管理功能；建立一系列獨(dú)有的，定制的大型的化合物庫，總的化合物數(shù)量在一百萬個左右；建立基于Calibr的ReFrame庫，重新建立一個包含15000多種化合物的藥物再開發(fā)化合物庫。

實(shí)驗(yàn)平臺建設(shè)：體外生物學(xué)實(shí)驗(yàn)室；藥物化學(xué)實(shí)驗(yàn)室；蛋白質(zhì)治療實(shí)驗(yàn)室；藥理學(xué)實(shí)驗(yàn)室。

Tenure-track assistant professor positions at Scripps Research | Shenzhen Bay Laboratory Chemical Biology Institute, Shenzhen, China

Scripps Research | Shenzhen Bay Laboratory Chemical Biology Institute is recruiting globally to fill multiple tenure-track assistant professor positions in Shenzhen, China.  The area of research is open but should fit within the broad scope of chemical and biological sciences, with emphasis on the interface between them in the context of disease and drug discovery.

Scripps Research | Shenzhen Bay Laboratory Chemical Biology Institute, Shenzhen, China, is a newly established partnership  between Scripps Research and Shenzhen Bay Laboratory (SZBL) (see reports at:

https://www.scripps.edu/news-and-events/press-room/2019/20191127-szbl-collaboration.html; and https://www.szbl.ac.cn/news_detail_en.aspx?detail=19746&parm=948).  Scripps Research — one of the world's largest, private, non-profit biomedical research organizations — is ranked the most influential institution in the world for its impact on innovation.  SZBL  strives to become a hub for world-class research at the forefront of health science and innovation.  The joint institute combines the expertise of both institutions to pursue basic and translational research at the intersection of biology and chemistry.

Qualified candidates should have a Ph.D. or M.D. degree, with postdoctoral training or industrial experience, and an outstanding record of research that demonstrates originality at addressing significant questions.  Successful candidates are expected to establish an active research group and pursue a program of high-quality research that will result in breakthrough discoveries or technology advancements.

Scripps Research | Shenzhen Bay Laboratory Chemical Biology Institute welcomes applicants of all nationalities and will provide an internationally competitive start-up package and salary.  Successful candidates will also receive a joint appointment from PKU Shenzhen Graduate School.  The initial appointment will be 5 years and renewal is based on reviews by an international committee.

Applicants should submit (1) curriculum vitae, (2) statement of research interests, (3) future research plans, and (4) three confidential letters of recommendation to email: wshen@scripps.edu or zyang@pku.edu.cn.  Applications will be reviewed on a rolling basis until all positions are filled.

Directors/Principal Investigators for Disease Biology (Job Code: SZBL 1001), Medicinal Chemistry (Job Code: SZBL 1002), in vivo Pharmacology (Job Code: SZBL 1003), Peptide, Protein and/or Antibody engineering (Job Code: SZBL 1004) and program management (Job Code: SZBL 1005)

About Scripps Research/Shenzhen Bay Laboratory Chemical Biology Institute; Shenzhen, China

Scripps Research is joining forces with Shenzhen Bay Laboratory to establish a joint Chemical Biology Institute (see announcements at: https://www.scripps.edu/news-and-events/press-room/2019/20191127-szbl-collaboration.html and https://www.szbl.ac.cn/news_detail_en.aspx?detail=19746&parm=948). Within this institute, the Division of Translational Research will consist of preclinical drug discovery and early drug development expertise and capabilities for small molecules, peptides/proteins and antibodies. Our state of the art facilities will include high throughput screening (HTS) and diverse small molecule libraries (1 million), with capabilities for medicinal chemistry optimization, peptide/protein and antibody engineering, PK and in vivo efficacy studies. Researchers will work closely with scientists from Calibr at Scripps Research, as well as collaborators within the Shenzhen Bay Laboratory and other institutions, to translate biomedical basic discoveries into innovative new drugs that will impact the major diseases of unmet need.

JOB SUMMARY

We are seeking talented PI/Director level managers in Disease Biology, Medicinal Chemistry, in vivo Pharmacology, Peptide, Protein and Antibody engineering to lead a dynamic, interdisciplinary team of research associates and post-doctoral scientists as well as coordinate CRO efforts to develop new therapeutic approaches to unmet medical needs through early stage translational research. Partnerships with various for-profit and non-profit organizations will be a key component of the workflow, and work will be published in high-impact, peer-reviewed journals.

RESPONSIBILITIES AND DUTIES

•     Responsible for developing and leading key research projects in alignment with the Institute’s mission and goals

•     Provides successful project and team leadership of both in-house and/or CRO resources

•     Uses in depth literature search skills to generate new project proposals and maintain a pipeline for successful pre-clinical candidates

•     Works with senior management to identify and develop new relevant and viable research projects and directions

•     Authors research reports, generates scientific presentations and manages research timelines

DECISION MAKING

Independently designs, executes, interprets and reports results of work.  Additionally, oversees consistency and accuracy of results and documentation. Exercise judgment to make decisions and solve problems independently.  Escalates issues and risks that significantly affect timelines.

COMMUNICATION

Strong communication skills that enable leadership of and coordination with colleagues, CRO personnel, and management teams to direct projects effectively. 

SCOPE AND COMPLEXITY

Principal Investigator is independently responsible for leading overall strategic as well as day-to-day research activities. Works collaboratively with teams in coordination of group goals.  Works on extremely complex problems and requires the ability to adapt quickly and evaluate intangible variables.  Exercise judgement in developing methods, techniques and criteria for obtaining results.

SUPERVISION OF OTHERS

Manages scientific staff related to applicable projects.  May have oversight of CRO relationship working to ensure goals and timelines are met accordingly. 

POSITION REQUIREMENTS

•     Candidates must have Ph.D. in a pertinent scientific field with 7+ years of related scientific experience and 3+ years of supervisory experience

•     Strong bench skills and a proven track record in area of specified science

•     Demonstration of highly successful project execution across disease areas using in-house and/or CRO resources leading to preclinical candidates for further clinical development

•     Demonstrated skills in managing, mentoring and supervising team members; commitment to diversity and inclusion

•     Highly motivated, creative, and devoted to project goals

•     Impeccable attention to detail, and excellent ability to perform hands on experiments, research, design, and organize project designs and maintain detailed documentation

•     Able to contribute in a meaningful way to scientific discourse

•     Prior involvement in drug discovery and early development in pharma settings are highly preferred

•     Highly motivated, creative, and able to maintain excellent documentation of their work including writing grant applications and third-party partnership plans

•     Able to collaborate proficiently and communicate effectively with colleagues, project management and senior leadership

Applicants should submit your curriculum vitae, cover letter and reference letters to email: wshen@scripps.edu.  Applications will be reviewed on a rolling basis until all positions are filled.

The above statements describe the level of work performed and expected in general terms.  The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of the Institute, with or without notice.

HTS engineer

Position Overview:

Automation Engineer/head of High Throughput Screening

Shenzhen Bay Laboratory is seeking a talented Automation Engineer/Head to lead the Automation and High Throughput Screening group.  The individual would be responsible for running, managing and maintaining laboratory automation as well as biochemical and cell-based assay development for HTS.  A successful candidate will have experience in lab automation, screening and assay development. 

Specialization in one or more the following is highly desirable: cell-based and biochemical assay development, High Content Imaging and Flow Cytometry or programming in Java, C# or related languages.  We are looking for someone who truly enjoys working with technology, so candidates with recreational interest in programming, auto repair, Arduino devices, etc. may be an especially good fit.

Essential Duties and Responsibilities:

•     Operate, maintain and troubleshoot uHTS System

•     Assay Development, Optimization and miniaturization

•     Troubleshooting screening issues related to both automation and assay conditions

•     Continual improvement of technologies through innovation

•     Data analysis of high throughput screens.

Qualifications and Experience:

Requirements

•     MS or PhD degree in engineering, biology or a relevant field with 2-5 years of experience in Lab Automation and Screening. 

•     Assay Development of Biochemical and cell-based assays

•     Experience running and troubleshooting Lab Automation including but not limited to liquid handling, acoustic dispensers, multi-mode readers, compound transfer devices, etc.

•     Ability to troubleshoot equipment problems and perform quality testing.

•     Working with teams to transition an assay from the bench to a high throughput screen.

•     Able to collaborate proficiently and communicate effectively with colleagues and management

•     High level of self-motivation.

Experience in one or more of the following is highly desirable

•     Programming in Java, C#, JavaScript and other languages

•     Programming and operation of the Labcyte Echo and Access system, Agilent Bravo, Tecan Freedom Evo, BMG Pherastar multi-reader, larger multi station-based systems such as HighRes and GNF Systems.

•     High Content Imaging and or Flow Cytometry

•     Cell based and biochemical assay development

•     Statistical Analysis and/or Design of Experiment

Compensation and Salary: $100k to $150k/y

Purpose of the initial working period at Calibr, Scripps Research:

•     Learn the cutting-edge technologies in uHTS systems

•     Help design the state of the art ultra HTS systems that fit the best need of the new institute in Shenzhen

•     Work with the vendors from various suppliers to assemble and integrate the uHTS system

•     Build-up first-hand experience in daily operation and maintenance, data acquisition and processing, and troubleshooting and service.

•     Facilitate alignment and future collaboration with Scripps Research.

Contact :

Please send the CV by email attachment to the Dr. Shen:wshen@scripps.edu 

Email subject: the title of the position for which you are applying.

For more details on SZBL and our research, please visit our website: www.szbl.ac.cn

Email content: please include your contact information, name, telephone number, and any dates on which you would be unavailable for an interview. Upon request, applications will be considered confidentially.

Compound Management Lead Candidate JO

The Position

This position will require the successful candidate to start a Compound Management group from the ground up. A strong background in Compound management is required. He/she will establish a workflow for sample request and fulfillment, select appropriate lab automation and software, receive requests for samples, track, coordinate, and perform order fulfillment and distribution of both solids, solutions, and plates to scientists.

Education and Experience:

•     Bachelor's degree in Engineering, Biochemistry, Chemistry or related field

•     5+ years experience the in a compound management, high throughput screening and/or lab automation

•     A proven track record managing a group.

•     Experience with liquid handling equipment and other laboratory automation technology systems. Experience with the span-8 liquid handlers (e.g. Tecan Evo, Hamilton Star), acoustic dispensers, plate transfer devices and related experience.

•     Proven track record of evaluating, selection, implementation of lab equipment and software  and the generation of SOPs.

•     Experience with LIMS and inventory management software.

The activities of the Compound Management Group include, but are not limited to, those shown below. Applicants should have experience in all the following:

•     Manual handling of all incoming compounds; including powder weighing, dissolution, and plating.

•     Handle logistical aspects of compound management; including sample inventory tracking and storage and ensure accurate record keeping.

•     Responsible for uploading data to compound registry, curation of registry, and managing data workflow.

•     Prioritize and communicate timelines; provide progress updates to the group.

•     Weighing and preparing compounds and solutions

•     Arraying compounds from vials to microtiter plates

•     Re-array compound plates

•     Maintaining and tracking compound library database

•     Provide support for sample receiving/sorting services, plate generation, screening, inventory maintaining and QC support using various liquid handling instruments for Compound Management.

•     Provide liquid handling performance monitoring services and other laboratory equipment maintenance per customer SOPs.

•     Keep accurate data entry of all activities in Tracking Database.

•     Provide operational flexibility by cross-training across all job functions with other team members.

•     Carefully follow customer SOP’s, orders, and schedules.

Proposed salary and benefit: ＄70k-100k/y

Purpose of the initial working period (6 months) at Calibr, Scripps Research:

•     Help assemble the key compound libraries for ultra HTS that fit the best need of the new institute in Shenzhen

•     Get trained with the appropriate lab automation and software

•     Familiarize with the workflow of sample requests and fulfillment, track, coordinate, and perform order fulfillment and distribution of both solids, solutions, and plates to scientists and CRO vendors

•     Build-up first-hand experience in daily operation and maintenance, library maintenance and replenishment and troubleshooting and service.

Contact:

Please send the CV by email attachment to the Dr. Shen: wshen@scripps.edu 

Email subject: the title of the position for which you are applying.

For more details on SZBL and our research, please visit our website: www.szbl.ac.cn

Email content: please include your contact information, name, telephone number, and any dates on which you would be unavailable for an interview. Upon request, applications will be considered confidentially.

蛋白組學(xué)質(zhì)譜應(yīng)用工程師

一、崗位工作內(nèi)容

1、負(fù)責(zé)蛋白質(zhì)組學(xué)樣品制備（包括各種樣品前處理方法和酶解等）、液相色譜串聯(lián)質(zhì)譜分析，以及質(zhì)譜相關(guān)操作方法的優(yōu)化開發(fā)；

2、負(fù)責(zé)基于質(zhì)譜的蛋白組學(xué)數(shù)據(jù)處理與分析，包括數(shù)據(jù)庫搜索等；

3、負(fù)責(zé)培訓(xùn)并指導(dǎo)實(shí)驗(yàn)人員完成相關(guān)實(shí)驗(yàn)操作；

4、負(fù)責(zé)蛋白組學(xué)質(zhì)譜的日常維護(hù)保養(yǎng)；

5、其它崗位相關(guān)工作。

二、應(yīng)聘條件

1、碩士及以上學(xué)歷；

2、分子生物學(xué)、生物化學(xué)、分析化學(xué)、細(xì)胞生物學(xué)等專業(yè)，有蛋白質(zhì)組學(xué)相關(guān)項(xiàng)目研究背景；

3、對蛋白質(zhì)組學(xué)有深入了解和研究，熟練掌握蛋白質(zhì)組學(xué)相關(guān)的理論、方法和應(yīng)用，熟悉蛋白質(zhì)組學(xué)相關(guān)數(shù)據(jù)庫及相關(guān)分析軟件，熟悉蛋白質(zhì)組學(xué)數(shù)據(jù)的統(tǒng)計與分析；

4、良好的英語閱讀及表達(dá)能力，有較強(qiáng)學(xué)習(xí)能力、溝通能力及團(tuán)隊(duì)協(xié)作精神。

三、工作條件和待遇

1、單位提供具有競爭力的薪資待遇，具體薪資和職位面議；

2、符合條件的申請人可申請深圳市相關(guān)配套待遇（如孔雀計劃等），深圳灣實(shí)驗(yàn)室可協(xié)助進(jìn)行申請。

四、應(yīng)聘者請?zhí)峁┮韵虏牧?/span>

1、個人簡歷；

2、《深圳灣實(shí)驗(yàn)室職位申請表》（見附件）

五、應(yīng)聘程序

1.    提交簡歷等材料：應(yīng)聘者請將應(yīng)聘材料發(fā)送至招聘專用郵箱hr_office@szbl.ac.cn，請?jiān)卩]件主題中標(biāo)明“深圳灣實(shí)驗(yàn)室+崗位名稱+姓名 ”。招聘小組在收到簡歷后，將通過電話以及郵件發(fā)送面試邀請。

2.    招聘考核及考核結(jié)果發(fā)布：招聘考核分為資格審查、專家面試等環(huán)節(jié)。面試通過后即發(fā)布錄用通知。

六、聯(lián)系人

聯(lián)系人：王老師；電話：0755-26653579；

Email：hr_office@szbl.ac.cn

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國博士人才網(wǎng)）