招聘簡介:

　　博士后職位

　　視網(wǎng)膜位置可在Retina生物化學(xué)和臨床疾病模型實驗室獲得，該實驗室位于加州大學(xué)洛杉磯分校斯坦因眼科研究所（https://apptrkr.com/1434138）新近裝修的最先進的研究空間。該候選人將對轉(zhuǎn)化研究有濃厚的興趣，該研究涉及將視網(wǎng)膜變性的臨床發(fā)現(xiàn)與基礎(chǔ)科學(xué)研究相結(jié)合。 Radu博士的實驗室致力于通過利用尖端技術(shù)開發(fā)和研究疾病系統(tǒng)（基于細胞和動物的模型）來識別和理解視網(wǎng)膜營養(yǎng)不良的分子機制。

　　Radu博士的研究小組確定了兩種獨立的途徑，這些途徑參與了Stargardt病的發(fā)病機制，這是一種青少年形式的黃斑變性，它將視網(wǎng)膜色素上皮細胞（RPE）作為疾病的主要部位：（1）有毒維生素A副產(chǎn)物的積累從視覺循環(huán)中視紫紅質(zhì)再生; （2）RPE細胞中補體系統(tǒng)的失調(diào)。探索這些途徑的交叉點是NEI R01資助支持的博士后獎學(xué)金的基礎(chǔ)。

　　英文原文：

　　Postdoctoral Position

　　A postdoctoral position is available in the Retina Biochemistry & Clinical Disease Modeling Laboratory in the newly renovated, state-of-the-art research space at the Stein Eye Institute, UCLA (https://apptrkr.com/1434138). The candidate will have a strong interest in translational research that involves integrating clinical findings of retinal degeneration with basic science research. Dr. Radu’s Lab focuses on identifying and understanding the molecular mechanisms of retinal dystrophies by developing and studying disease systems (both cell- and animal-based models) utilizing cutting-edge technologies.

　　Dr. Radu’s group identified two independent pathways involved in the pathogenesis of Stargardt disease, a juvenile form of macular degeneration, which implicate the retinal pigment epithelium (RPE) as the major site of the disease: (1) accumulation of toxic vitamin A byproducts derived from the visual cycle for rhodopsin regeneration; and (2) dysregulation of the complement system in the RPE cells. Exploring the intersection of these pathways is the basis for this postdoctoral fellowship supported by an NEI R01 grant.

　　The postdoctoral candidate will be expected to design and perform the relevant functional studies using RPE cultured cells derived from human samples. The applicant will also be tasked with implementing in vivo experiments using complex-genetic animal models. We are seeking an independent and motivated individual with excellent organizational, interpersonal, and communication skills (both verbal and written).

　　Candidates are expected to hold a Ph.D. and/or M.D. with less than 2 years of postdoctoral experience, be self-motivated and demonstrate a record of research achievement. A strong background in mouse genetics, biochemistry, cell biology, primary cell isolation, cell transfection, cell-based assays, nucleic acid and protein manipulation, proficiency in microscopy and data analysis are necessary.

　　Please send a Curriculum Vitae with a complete bibliography and the names of three professional references to Principal Investigator Roxana Radu, MD at radu@jsei.ucla.edu.

　　The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: UC Nondiscrimination and Affirmative Action Policy.

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國博士人才網(wǎng)）