招聘簡(jiǎn)介：

　　海德堡大學(xué)醫(yī)院

　　急性髓系白血病，RNA 修飾方向

　　博士/博士后

　　申請(qǐng)者應(yīng)具備生物化學(xué)，細(xì)胞分子生物學(xué)，遺傳學(xué)或者基礎(chǔ)/臨床醫(yī)學(xué)等相關(guān)背景和學(xué)位。具有扎實(shí)的基礎(chǔ)實(shí)驗(yàn)技術(shù)，包括 Western blotting, gene expression analysis, cloning, cell culture, flow cytometry, protein Co-Immunoprecipitation, RNA immunoprecipitation, Chromatin immunoprecipitation 等。有動(dòng)物實(shí)驗(yàn)經(jīng)驗(yàn)，高通量測(cè)序文庫(kù)構(gòu)建，數(shù)據(jù)分析優(yōu)先考慮。能熟練使用英語交流，匯報(bào)工作，撰寫論文。德語不做要求。我們將為您提供標(biāo)準(zhǔn)的工資待遇，優(yōu)越的工作條件和科研環(huán)境，廣泛的合作機(jī)會(huì)。有興趣者請(qǐng)將您的申請(qǐng)材料（請(qǐng)整理為一個(gè)PDF文檔，大小不超過5MB，命名格式Postdoc  03-2019 - family name ）發(fā)送至annette.becker@med.uni-heidelberg.de.

　　招聘原文：

　　Postdoc position (m/f/d)

　　full-time - JobID: P0071V037

　　One postdoctoral position is immediately available at the Heidelberg University Hospital, Department of Hematology, Oncology and Rheumatology. This position will be funded by DFG (Deutsche Forschungsgemeinschaft, project leader: Dr. Fengbiao Zhou).

　　The position is limited to 2 years with the option of further extension. We are looking for a highly motivated, skilled and communicative Postdoc who is interested to perform competitive high quality scientific research in the area of acute myeloid leukemia. Our research group under the lead of Prof. Carsten Müller-Tidow focuses on leukemic stem cells and therapy resistance.

　　This project focuses on post-transcriptional modifications on RNAs, RNA binding proteins and their functional roles in mRNA splicing translation control in the pathology of acute myeloid leukemia. We aim to understand how epitranscriptomics participates in the leukemia stem cell regulation and chemo-resistance in AML, with the final aim to translate the experimental findings into novel therapy approaches for AML patients. Related Publications: Zhou, F et al,. Nature Cell Biology, April 2017. For more information, please visit http://lab.mueller-tidow.de.

　　Potential applicants should have

　　· Doctoral-level degree with solid background on biochemistry, genetics and molecular and cellular biology

　　· Broad expertise in basic cell-, molecular and biochemical techniques (Western blotting, gene expression analysis, cloning, cell culture, flow cytometry, protein Co-Immunoprecipitation, RNA immunoprecipitation, Chromatin immunoprecipitation etc.)

　　· Good knowledge of and experience with statistical software (SPSS), bioinformatics tools, next generation sequencing library prep is preferred

　　· Experience with syngeneic and/or xenograft mouse models is a plus

　　· High motivation to work hard in a competitive research field

　　· First experience in writing scientific reports and papers

　　· Strong communication skills, fluent in written and spoken English and German

　　The postdoc will work closely with a team of enthusiastic biologists and medical scientists

　　We offer

　　· An exciting and highly translational research project

　　· Access to state of the art equipment, access to the core facilities in our department and in Heidelberg University including flow cytometry and sorter, proteomics platform, metabolites platform, high throughput sequencing facility, advanced microscopy core facility, on-site mouse facilities and so on. Quantitative unique samples from healthy donors and patients are also project-related accessible via the department’s biobank

　　· Presentation and publication of the data at international scientific conferences and in journals

　　· Collaboration with many other experimentally or theoretically oriented labs on top level in the University hospital, in the Heidelberg area (DKFZ, EMBL) and with international research partners

　　· Additionally we offer individual, target-oriented advanced training, ticket for public transport, health promotion, and university sports/library

　　Contact & Application

　　For further information you may contact: Annette Becker, M.A., Science coordinator, phone +49(0) 6221 56-8552, Department of Hematology, Oncology, Rheumatology, Heidelberg University Hospital.

　　Applications with reference Postdoc  03-2019 - family name should be sent by email as one single pdf-file (max 5 MB) to annette.becker@med.uni-heidelberg.de. You are invited to send within this file a covering letter / supporting statement, including a brief statement of research interests, CV, university degrees and the details of referees and references.

　　Please do not send original documents by mail services, since they will not be returned.

　　Universitätsklinikum Heidelberg

　　Zentrum für Innere Medizin

　　Klinik für Hämatologie, Onkologie, Rheumatologie (Innere Medizin V)

　　Annette Becker

　　Im Neuenheimer Feld 410

　　69120 Heidelberg

　　annette.becker@med.uni-heidelberg.de

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