博后招聘——30 萬年薪，“生物-醫(yī)學(xué)-信息-工程”學(xué)科交叉，國(guó)際名校合作研究
Postdoctoral Researcher Recruitment

WHO WE ARE

浙江大學(xué)愛丁堡大學(xué)聯(lián)合學(xué)院（ZJE）坐落于浙江大學(xué)海寧國(guó)際校區(qū)，是由浙江大學(xué)（2019QS世界排名第54位）和英國(guó)愛丁堡大學(xué)（2019QS世界排名第20位）合作成立的非獨(dú)立法人中外合作辦學(xué)機(jī)構(gòu)，專注于探索“生物-醫(yī)學(xué)-信息-工程”學(xué)科交叉研究。

The Zhejiang University-University of Edinburgh Institute (ZJE) is based in state of the art facilities at the new International Campus in Haining, Zhejiang, P.R.China. The new Institute, established by two world-leading universities, Zhejiang University and University of Edinburgh, is focused on international Biomedical Sciences/Bioinformatics/Biomedical Informatics/Biomedical Engineer research collaboration.

ZJE正與浙江大學(xué)醫(yī)學(xué)院附屬第二醫(yī)院開展戰(zhàn)略合作，探索以疾病診療為導(dǎo)向的生物醫(yī)學(xué)前沿聯(lián)合研究。

ZJE is carrying out strategic cooperation with the Second Affiliated Hospital of Zhejiang University School of Medicine to explore frontier research on biomedical sciences oriented by disease diagnosis and treatment.

了解更多信息，請(qǐng)查閱以下網(wǎng)址：

To learn more information about the institute, please refer to the websites below:

http://zje.zju.edu.cn (ZJE, 浙江大學(xué)愛丁堡大學(xué)聯(lián)合學(xué)院)

http://www.intl.zju.edu.cn (International Campus, ZJU, 浙江大學(xué)海寧國(guó)際校區(qū))

http://www.zju.edu.cn (Zhejiang University，浙江大學(xué))

https://www.ed.ac.uk (the University of Edinburgh，愛丁堡大學(xué))

http://www.z2hospital.com (the Second Affiliated School of Zhejiang University School of Medicine，浙江大學(xué)醫(yī)學(xué)院附屬第二醫(yī)院)

WHAT WE ARE LOOKING FOR

ZJE面向全球誠(chéng)聘博士后研究人員，學(xué)科領(lǐng)域涵蓋干細(xì)胞和再生醫(yī)學(xué)、免疫學(xué)、生物化學(xué)和分子生物學(xué)、細(xì)胞生物學(xué)和病原微生物學(xué)等。

ZJE is now seeking applications for postdoctoral positions from around the world. Research themes include: Stem Cell and Regenerative Medicine, Immunology, Biochemistry and Molecular Biology, Cellular Biology, Pathogenic Microbiology.

應(yīng)聘要求Qualifications

申請(qǐng)者需擁有生物學(xué)、醫(yī)學(xué)、生物醫(yī)學(xué)、生物信息學(xué)和公共健康等相關(guān)領(lǐng)域博士學(xué)位，已在國(guó)際刊物上發(fā)表過較好研究論文者優(yōu)先考慮。

Applicants will be expected to have a PhD in biology, medical science, biomedical science, bioinformatics, public health or a related field and show evidence of their research achievements and potential.

導(dǎo)師和項(xiàng)目詳情For more information about projects and mentors:

干細(xì)胞和再生醫(yī)學(xué)Stem Cell and Regenerative Medicine：

歐陽(yáng)宏偉Hongwei Ouyang: hwoy@zju.edu.cn

個(gè)人主頁(yè)Website: http://person.zju.edu.cn/en/ouyanghongwei

研究領(lǐng)域Research:

歐陽(yáng)宏偉教授長(zhǎng)期從事干細(xì)胞與骨、軟骨、肌腱組織的再生研究，先后獲批國(guó)家級(jí)、省部級(jí)科研項(xiàng)目近20項(xiàng)。

Prof. Ouyang Hongwei focuses on the research of stem cell and regenerative medicine, sports medicine, tissue engineering and biomedical materials.

黃雯雯Wenwen Huang: wenwenhuang@intl.zju.edu.cn

個(gè)人主頁(yè)Website: https://person.zju.edu.cn/wenwenhuang

研究領(lǐng)域Research:

本課題組致力于設(shè)計(jì)開發(fā)具有特定功能的人造蛋白材料，以滿足當(dāng)前資源、能源、環(huán)境等可持續(xù)發(fā)展策略對(duì)新材料的迫切需求。本實(shí)驗(yàn)室通過將生物物理、生物工程以及醫(yī)學(xué)等領(lǐng)域進(jìn)行交叉融合，建立了以蛋白功能為導(dǎo)向、以生物合成和多尺度模擬為基礎(chǔ)、以高通量制備分析和功能測(cè)試為驗(yàn)證和優(yōu)化手段的人造蛋白功能材料創(chuàng)制體系。主要研究方向?yàn)椋?/span>1）蛋白質(zhì)序列-結(jié)構(gòu)-功能的關(guān)系以及蛋白質(zhì)材料對(duì)人體組織/細(xì)胞生長(zhǎng)分化的影響；（2）智能蛋白質(zhì)材料設(shè)計(jì)、高通量篩選、蛋白質(zhì)自組裝理論研究和蛋白質(zhì)材料物理化學(xué)改性；（3）蛋白質(zhì)基柔性電子設(shè)備研發(fā)等應(yīng)用方面的研究工作。

Dr. Huang’s lab focuses on predictive design, synthesis and functionalization of protein-based biomaterials for regenerative medicine and sustainable bio-electronics. Current research projects include: (1) injectable hydrogel and stem cell engineering, (2) stimuli-responsive biomaterial design, and (3) flexible electronics. Postdoc positions are available for highly motivated candidates with expertise in synthetic biology, material science and stem cell engineering.

劉琬璐Wanlu Liu: wanluliu@intl.zju.edu.cn

個(gè)人主頁(yè)Website: https://person.zju.edu.cn/labw

研究領(lǐng)域Research:

本課題組通過多學(xué)科交叉，結(jié)合基因組學(xué)(RNA-seq, Bisulfite sequencing, ChIP-seq, ATAC-seq, Hi-C, single cell-based sequencing)、分子生物學(xué)以及生物信息學(xué)，來研究表觀遺傳在調(diào)控細(xì)胞 命運(yùn)決定過程中的起到的在基礎(chǔ)科學(xué)層面以及臨床轉(zhuǎn)化方面相關(guān)的問題。主要的研究方向包括:1)研究轉(zhuǎn)座子在細(xì)胞命運(yùn)決定過程中涉及的表觀遺傳調(diào)控相關(guān)問題。2)開發(fā)用于預(yù)測(cè)細(xì)胞命運(yùn)的基于機(jī)器學(xué)習(xí)/深度學(xué)習(xí)相關(guān)的基因組學(xué)算法。3) 基于表觀遺傳組學(xué)的疾病分型以及疾病預(yù)測(cè)。

1) understand the epigenetic basis of transposable elements in cell fate descisions. 2) develop machine learning based algorithm to predict cell fate.

陳迪Di Chen: dichen@intl.zju.edu.cn

個(gè)人主頁(yè)Website: http://labchen.cn

研究領(lǐng)域Research:

陳迪博士的實(shí)驗(yàn)室研究人類胚胎發(fā)育和胚胎干細(xì)胞分化的調(diào)控。目前，陳迪實(shí)驗(yàn)室招聘數(shù)位博后，主要研究課題包括：

（1）人類胚胎干細(xì)胞分化在表觀遺傳層面以及轉(zhuǎn)錄后層面的調(diào)控。

（2）RNA-結(jié)合蛋白在人類原始生殖細(xì)胞誘導(dǎo)和分化過程中的功能。

（3）決定細(xì)胞命運(yùn)的轉(zhuǎn)錄因子在人類胚胎干細(xì)胞分化過程中的新功能。

Dr. Chen’s lab focuses on the regulation of human embryogenesis and embryonic stem cell differentiation. Postdoc positions are available in Chen lab for the following projects

(1) The regulation of human embryonic stem cell differentiation at epigenetic and post-transcriptional levels.

(2) The function of RNA-binding protein during human primordial germ cell specification and differentiation.

(3) The new functions of cell fate determinant transcription factors during embryonic stem cell differentiation.

生物化學(xué)和分子生物學(xué)Biochemistry and Molecular Biology

Sebastian Leptihn: leptihn@intl.zju.edu.cn

個(gè)人主頁(yè)Website: https://person.zju.edu.cn/en/H118035

研究領(lǐng)域Research: The Leptihn Group offers two Postdoctoral Fellowships; one project focusses on the investigation of membrane proteins controlling cellular signalling pathways employing microfluidics and single molecule methods (fluorescence, electrophysiology) together with the University of Edinburgh and the ZJUI (Zhejiang University-University of Illinois Urbana Champagne). The second project involves viruses of microbes (bacteriophages) with aspects on both, function and structure of phage proteins, as well as phage therapy. Experience in imaging and protein biochemistry or microbiology are desired.

洪智Zhi Hong: zhihong@intl.zju.edu.cn

個(gè)人主頁(yè)Website: https://person.zju.edu.cn/en/hongzhi

研究領(lǐng)域Research:

本課題組將從細(xì)胞器交流角度解析細(xì)胞-外界環(huán)境的相互作用，即外界環(huán)境變化（特指外源的能量供給變化）對(duì)細(xì)胞器互作結(jié)構(gòu)特質(zhì)（property）/穩(wěn)態(tài)（homeostasis）的影響。直接研究方向主要集中在兩個(gè)方面：1）結(jié)合領(lǐng)域內(nèi)已知和本人的前期數(shù)據(jù)，對(duì)細(xì)胞器互作網(wǎng)絡(luò)改變細(xì)胞器膜脂組成和蛋白成分進(jìn)行深入的機(jī)制研究。2）利用新的生物標(biāo)記或技術(shù)從亞細(xì)胞器水平上發(fā)現(xiàn)細(xì)胞器互作網(wǎng)絡(luò)對(duì)單個(gè)細(xì)胞器的影響，進(jìn)一步拓展我們對(duì)細(xì)胞器互作網(wǎng)絡(luò)的功能認(rèn)知。

1. The regulation of organelle-organelle crosstalk on biogenesis-maturation- location of organelles.

2. The function or contribution of organelle-organelle crosstalk in stress response.

病原微生物學(xué)Pathogenic Microbiology

Sue Welburn: sue.welburn@ed.ac.uk

個(gè)人主頁(yè)Website:http://www.ed.ac.uk/pathway-medicine/our-staff/staff-profiles/profsuewelburn

研究領(lǐng)域Research:

Sue focuses on interventions for disease control in the Global South, with on-going projects in Kenya, Morocco, Mozambique, Tanzania, Uganda, Nigeria, Zambia and Zanzibar.

免疫學(xué)Immunology

魯林榮Linrong Lu：lu_linrong@zju.edu.cn

個(gè)人主頁(yè)Website: http://person.zju.edu.cn/en/llr

研究領(lǐng)域Research:

本實(shí)驗(yàn)室旨在用分子生物學(xué)、細(xì)胞生物學(xué)和實(shí)驗(yàn)動(dòng)物模型等研究手段揭示免疫調(diào)節(jié)的機(jī)制。尤其對(duì)胸腺T細(xì)胞發(fā)育、CD8+ T細(xì)胞亞群和具有免疫調(diào)節(jié)功能新分子的研究感興趣，同時(shí)對(duì)自身免疫性疾病和腫瘤的免疫治療的策略進(jìn)行研究。

研究手段：分子生物學(xué)，細(xì)胞培養(yǎng)，基因敲除，自身免疫性疾病動(dòng)物模型

正在開展的課題：

1）CD8+ T細(xì)胞亞群與自身免疫性疾病與抗腫瘤免疫

2）胸腺T細(xì)胞的發(fā)育分化

3）T細(xì)胞分化的信號(hào)傳導(dǎo)調(diào)控

4）固有免疫的信號(hào)傳導(dǎo)和基因表達(dá)調(diào)控

The main focus of our lab is to elucidate the molecular pathways and cellular interactions that mediate and regulate thymocyte development and T cell-mediated immune responses by using molecular biology and genetic approaches. We are especially interested in the identification and characterization of novel immune-related molecules and the development and treatment of autoimmune diseases.

細(xì)胞生物學(xué)Cellular Biology

郭偉Wei Guo: weiguo@intl.zju.edu.cn

個(gè)人主頁(yè)Website: https://person.zju.edu.cn/en/gwlab

研究領(lǐng)域Research:

郭博士從事干細(xì)胞和癌癥的研究，精于人類和小鼠遺傳學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)，生物醫(yī)學(xué)，及基因組學(xué)的方法。他在造血發(fā)育、白血病干細(xì)胞以及腫瘤耐藥調(diào)控方面等有重要建樹。他建立了第一個(gè)由PTEN缺失導(dǎo)致T細(xì)胞急性白血病的小鼠模型，促成臨床發(fā)現(xiàn)只帶有PTEN突變而沒有NOTCH1突變的嬰幼兒T細(xì)胞白血病病人。他首次分離了T細(xì)胞急性白血病干細(xì)胞，揭示出了多因子突變導(dǎo)致白血病干細(xì)胞形成的過程，并發(fā)現(xiàn)了mTOR抑制劑的雙重抗癌機(jī)制。近來，郭博士課題組從臨床肺腫瘤中分離出腫瘤干細(xì)胞，并發(fā)現(xiàn)NOTCH1信號(hào)通路調(diào)控肺腫瘤干細(xì)胞的自我更新和鉑類耐藥。

Dr. Wei Guo laboratory uses basic biological approaches to understand biomedical challenges and translates its understanding to clinical practice. There are two major research directions: (1) stress response and ex vivo expansion of hematopoietic stem cells; and (2) regulation and targeted inhibition of cancer resistance.

謝昕Xin Xie: xinxie@intl.zju.edu.cn

個(gè)人主頁(yè)Website: https://person.zju.edu.cn/en/xinxie

研究領(lǐng)域:

研究方向：課題組運(yùn)用分子生物學(xué)、細(xì)胞生物學(xué)、生物信息學(xué)、3D類器官培養(yǎng)和轉(zhuǎn)基因小鼠模型研究干細(xì)胞命運(yùn)控制，衰老及相關(guān)疾病的靶向治療。

正在開展的課題：

1）腸干細(xì)胞穩(wěn)態(tài)平衡、惡性轉(zhuǎn)化及腸道疾病的早期診療。運(yùn)用生物信息學(xué)分析、小鼠模型和腸道類器官，我們將深入研究大腸腫瘤干細(xì)胞的惡性轉(zhuǎn)化和腫瘤轉(zhuǎn)移的分子機(jī)制，并開展臨床轉(zhuǎn)化研究。

2）干細(xì)胞發(fā)育、衰老和融合的信號(hào)調(diào)控。實(shí)驗(yàn)室的最新成果揭示了首個(gè)永久性的阻斷體內(nèi)細(xì)胞融合的動(dòng)物模型。在此基礎(chǔ)上，我們將進(jìn)一步探討細(xì)胞融合與衰老的分子機(jī)理。

3）肌肉萎縮癥，糖尿病和肥胖的靶向治療。實(shí)驗(yàn)室已發(fā)表的研究證實(shí)了新的疾病治療靶點(diǎn)。為此，我們將運(yùn)用高通量篩選實(shí)驗(yàn)找尋靶點(diǎn)基因的小分子抑制劑，進(jìn)行臨床前期研究。

We investigate signaling molecules within adult stem cells (intestinal、muscle and mesenchymal stem cells) regulate their fundamental properties in both physiological and pathological conditions.

Research interest: adult stem cell and related disorders

1. Intestinal stem cell, colorectal cancer and inflammatory bowel disease

2. Mesenchymal stem cell, muscle stem cell, musculoskeletal disorders and metabolic syndrome

Mikael Bjorklund: mikaelbj@intl.zju.edu.cn

個(gè)人主頁(yè)Website: https://person.zju.edu.cn/en/H118035

研究領(lǐng)域Research:

本實(shí)驗(yàn)室主攻癌癥細(xì)胞生物學(xué)，致力于腫瘤細(xì)胞生長(zhǎng)和代謝(參見我們的論文《Dev Cell, 2016》，《Trends in Cell Biology, 2017》)。我們使用定量和基因組數(shù)據(jù)來了解細(xì)胞大小、細(xì)胞生長(zhǎng)和代謝之間的關(guān)系。我們實(shí)驗(yàn)室在熱蛋白組學(xué)分析處于前沿行列（參見我們的論文《EMBO J, 2018》），并以此技術(shù)來研究藥物和代謝物與細(xì)胞蛋白之間的相互作用。我們的項(xiàng)目結(jié)合了信息學(xué)和實(shí)驗(yàn)細(xì)胞生物學(xué)，因此我們非常歡迎來自不同科學(xué)背景的候選人提出申請(qǐng)。具有生物信息學(xué)、計(jì)算機(jī)科學(xué)或物理學(xué)背景者將優(yōu)先考慮。

Mikael Bjorklund lab works on cancer cell biology, focusing on cell growth and metabolism (Dev Cell, 2016; EMBO J, 2018). The main interest in the laboratory is how metabolism, particularly mitochondria, and cell size impact cellular fitness and functions.

Ting Gang Chew: tinggchew@intl.zju.edu.cn

個(gè)人主頁(yè)Website: https://person.zju.edu.cn/en/H118023

研究領(lǐng)域Research:

細(xì)胞通過感知和轉(zhuǎn)導(dǎo)機(jī)械力信號(hào)來產(chǎn)生恰當(dāng)?shù)陌麅?nèi)生物化學(xué)應(yīng)答。細(xì)胞內(nèi)外的機(jī)械力都有助于胞質(zhì)分裂的成功，從而使一個(gè)細(xì)胞分裂為兩個(gè)子細(xì)胞。研究表明細(xì)胞胞質(zhì)分裂的失敗與基因組不穩(wěn)定性、腫瘤進(jìn)化和衰老緊密關(guān)聯(lián)，而胞質(zhì)分裂的成功則與細(xì)胞動(dòng)力學(xué)和細(xì)胞外基質(zhì)的相互作用密切相關(guān)。我們的研究目的是探究胞質(zhì)分裂在衰老或其它病理狀況下的對(duì)細(xì)胞外基質(zhì)不同剛度反應(yīng)的機(jī)械力學(xué)和動(dòng)力學(xué)機(jī)制。為此，我的實(shí)驗(yàn)室聯(lián)合采用化學(xué)遺傳學(xué)、光遺傳學(xué)和高分辨率活細(xì)胞顯微成像技術(shù)探究胞質(zhì)分裂失敗產(chǎn)生的結(jié)果和胞質(zhì)分裂的機(jī)械生物學(xué)機(jī)制。

Cells sense and transduce mechanical signals to generate appropriate biochemical and cellular response. Both the cellular and extracellular mechanics contribute to the success of cytokinesis, which is the division of one cell into two. Failure of cytokinesis is implicated in genomic instability, tumor evolution, and aging. The success of cytokinesis is linked to the proper interaction of cytokinetic machinery and the extracellular matrix. We aim to study the mechanics and dynamics of cytokinesis in response to different extracellular matrix stiffness during aging or other pathological conditions. To this end, my lab couple chemical genetics, optogenetics and high resolution live cell microscopy imaging to study the mechanobiology of cytokinesis and the consequences of its failure.

王超塵Chaochen Wang： chaochenwang@intl.zju.edu.cn

個(gè)人主頁(yè)Website: https://person.zju.edu.cn/en/H118068

研究領(lǐng)域Research:

實(shí)驗(yàn)室充分利用高通量測(cè)序，以CRISPR介導(dǎo)的基因編輯和表觀遺傳編輯為主要技術(shù)手段，結(jié)合生物信息學(xué)分析,  充分結(jié)合基因組學(xué)、表觀遺傳學(xué)、信息學(xué)、基因編輯技術(shù)和動(dòng)物體內(nèi)篩選模型，致力于以臨床疾病為導(dǎo)向的表觀遺傳學(xué)方向的研究。研究方向分為基礎(chǔ)和臨床研究?jī)蓚�(gè)部分，并相互交叉。

實(shí)驗(yàn)室目前主要研究方向包括：

1）細(xì)胞命運(yùn)改變的表觀遺傳調(diào)控機(jī)制研究

2）基因編輯及表觀遺傳編輯工具研究

3）乳腺發(fā)育及乳腺癌發(fā)生的分子機(jī)制及免疫調(diào)節(jié)機(jī)制研究

Dr Chaochen Wang’s lab focuses on dissecting the molecular mechanisms underlying the cell fate transition during ESC differentiation, mammary gland development and tumorigenesis. Leveraging CRISPR-mediated genome and epigenome engineering tools, NGS and bioinformatics, his lab aims for making prominent impact on stem cell study, cancer diagnosis and prognosis in a long run.

Kuan Yoow Chan: kychan@intl.zju.edu.cn

個(gè)人主頁(yè)Website: https://person.zju.edu.cn/en/H118031

研究領(lǐng)域Research:

The centrosome is an important signalling and microtubule organizing centre in mammalian cells. Centrosomal defects are a common in high grade cancer and have been shown to trigger tumorigenesis in mice. The impact of centrosomal defects in deregulating the cell cycle in cancer is poorly understood. In addition, cancer genome sequencing efforts worldwide show mutations on centrosomal components are common. Using genetic, cell biology and biochemical assays, we aim to study how the changes in centrosomal signalling lead to the deregulation of the cell cycle in cancer.

WHAT WE OFFER

應(yīng)聘者將與浙江大學(xué)簽訂合同，工作地點(diǎn)為海寧國(guó)際校區(qū)。

The posts will be located at ZJE Institute in Haining and the contract of employment will be held with Zhejiang University.

薪資及待遇Salary and Benefits

1）薪資待遇參照浙江大學(xué)博士后招聘相關(guān)政策執(zhí)行，年薪最高可達(dá)人民幣30萬元。

Salary is commensurate with qualifications and experience, compliant with policies for postdoctoral recruitment in Zhejiang University. Annual pay is in the region of 300,000 RMB.

2）學(xué)校有償提供教師公寓（優(yōu)惠價(jià)格租賃）、支持申請(qǐng)國(guó)家自然科學(xué)基金，鼓勵(lì)支持在站期間申報(bào)各類博士后基金和國(guó)際交流專項(xiàng)計(jì)劃資助。

Postdoc Fellows is eligible to rent staff apartments at favorable price, and is encouraged to apply for NSFC、Postdoctoral Funding and International Exchange Funding.

3）ZJE為博士后研究人員提供國(guó)際化科研環(huán)境以及國(guó)際學(xué)術(shù)交流的機(jī)會(huì)。

ZJE provides an excellent research environment and opportunities for international academic exchange.

HOW TO APPLY

應(yīng)聘材料Application Materials：

1） 簡(jiǎn)歷Your CV

2）學(xué)歷學(xué)位證書Certificates of education experience

3）科研經(jīng)歷和學(xué)術(shù)成就簡(jiǎn)述A summary of your research experience to date

4）2封推薦信（其中一封來自博士期間導(dǎo)師）Two references from experts in your scientific field (one from your PhD supervisor)

請(qǐng)將應(yīng)聘材料直接發(fā)至你感興趣的導(dǎo)師郵箱，或發(fā)給學(xué)院公共郵箱（uoe@zju.edu.cn）并注明感興趣的導(dǎo)師 。

Email to mentors whose research fields fit yours or to our admin team (uoe@zju.edu.cn)Email Title:tutor+gaoxiaojob.

為防止簡(jiǎn)歷投遞丟失請(qǐng)抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國(guó)博士人才網(wǎng)）