Research Fellow in Protein Chemistry for Targeted Drug DeliveryUniversity of Leeds
Description
Working closely with a second research fellow in the School of Physics & Astronomy, you will join a multidisciplinary team based in the Schools of Chemistry, Physics & Astronomy, Medicine and Electronic Engineering (Prof Bruce Turnbull, Prof Steve Evans, Dr Zhan Ong, Dr Jon Sandoe and Prof Steve Freear) to work on an EPSRC funded project to develop the use of microbubbles for targeting and treatment of microbial biofilm infections.
Antibiotics are becoming less effective because of resistance developed by bacteria. We aim to combat antibiotic resistance by developing better antibiotics as well as improving the way we use existing ones. In this project we will use microbubbles, similar to those already used as ultrasound scanning contrast agents, to deliver antibiotics directly to a site of infection. You will develop methods to conjugate the bubbles to proteins that target bacterial biofilms and assess their molecular targeting activity in microfluidic systems under flow conditions. You will investigate if combinations of molecular targeting proteins improve biofilm targeting. You will also perform experiments to load liposomes with antimicrobial peptides, and attach them to the microbubbles. You will perform drug release studies to investigate if the combined use of targeted microbubbles and ultrasound drug release methods can provide enhanced antibiotic efficiency.
To explore the post further or for any queries you may have, please contact:
Professor Bruce Turnbull
Tel: +44 (0)113 343 7438
Email: w.b.turnbull@leeds.ac.uk
為防止簡(jiǎn)歷投遞丟失請(qǐng)抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國(guó)博士人才網(wǎng)）
中國(guó)-博士人才網(wǎng)發(fā)布
聲明提示：凡本網(wǎng)注明“來(lái)源：XXX”的文/圖等稿件，本網(wǎng)轉(zhuǎn)載出于傳遞更多信息及方便產(chǎn)業(yè)探討之目的，并不意味著本站贊同其觀點(diǎn)或證實(shí)其內(nèi)容的真實(shí)性，文章內(nèi)容僅供參考。
